Target ranking
Gene prioritization
SpatioCellularRisk prioritization Score ranks candidate genes by high-risk specificity, perturbation rescue, clinical bulk evidence, external cancer relevance and high-risk communication.
Prioritization table
CSVGene × evidence type
Evidence guide
- Bulk high-risk
- Positive significant logFC in high-risk bulk groups.
- Single-cell high-risk
- Positive significant logFC in high-risk cells.
- Spatial high-risk
- Positive significant logFC in high-risk spatial niches.
- Single-cell rescue
- Virtual KO rescue minus risk gain in single cells.
- Spatial rescue
- Virtual KO rescue minus risk gain in spatial spots.
- Tumor-normal
- Positive significant tumor-normal logFC.
- Prognosis
- Significant HR above 1 in gene-level Cox analysis.
- External relevance
- GeneCards and CTD raw scores normalized within cancer.
- Communication
- Ligand/receptor pair count in high-risk cell communication.